Strom Levagen is produced using pure Levagen, at a dose of 300mg per cap, 60 capsules per bottle.
Levagen® is a trademarked name for a supplement ingredient called palmitoylethanolamide (PEA). Palmitoylethanolamide is a fatty acid amide naturally produced in the body and found in various food sources, such as eggs, soybeans, and peanuts. It is believed to interact with certain receptors in the body's endocannabinoid system.
Palmitoylethanolamide has demonstrated functions in supporting pain management, joint and cartilage health, inflammatory response, and immune response.
Levagen® is a trademarked name for a supplement ingredient called palmitoylethanolamide (PEA). Palmitoylethanolamide is a fatty acid amide naturally produced in the body and found in various food sources, such as eggs, soybeans, and peanuts. It is believed to interact with certain receptors in the body's endocannabinoid system.
Palmitoylethanolamide has demonstrated functions in supporting pain management, joint and cartilage health, inflammatory response, and immune response.
What is levagen and what does it do?
The first point of understanding is that Levagen is the standalone compound Palmitoylethanolamide, but manufactured in such a way with the quality assurance that we can always expect a high degree of purity.
This is similar to the ethos of Alzchem's CreaPure, it's just creatine... but a creatine we can always have confidence that it is in fact what it claims to be which we can't say for the wider market right now. Levagen is the same.
The role of quality assured products like this are valuable in the supplement industry as we can use the as a benchmark to compare others against. In this case the wider Palmitoylethanolamide industry appears to suffer quality issues, being poor in performance compared to Levagen, some other branded "Pure" PEA products having as low as 50% yield. See reference [x] for third party research regarding
What does naturally occurring Palmitoylethanolamide do in the body?
Palmitoylethanolamide is a naturally occurring compound that our body does already produce, synthesized from palmitic acid, which is the most common fatty acid in animals and a product of normal fatty acid synthesis.
It is generally accepted that most tissues in the body will produce Palmitoylethanolamide in increased concentrations in response to inflammatory stress, whereupon it is freely available to act in an anti-inflammatory manner - including the direct activation of PPAR-a and GPR55 receptors and the indirect activation of cannabinoid receptors (CB1 and CB2) and TRPV1 channels. This has a valuable role in regulation of inflammatory cytokine response, notable for any source of inflammation but with well documented research around joint inflammation, inflammation related immune disorders, brain inflammation, and influenza related. Other research shows functions in sleep modulation.
PEA is endogenously produced on-demand in most tissues, as a protective response to injury, inflammation and pain.
What does Supplemental Palmitoylethanolamide do in the body?
When orally consumed Palmitoylethanolamide is able to enter circulation through the digestive tract. Once in circulation, Palmitoylethanolamide acts on out body in the same way as normally produced Palmitoylethanolamide. When pain is protracted, however, PEA ‘exhaustion’ may develop. Chronic inflammatory conditions create lower levels of PEA. The exogenous administration of PEA may in such cases serve to replenish levels of endogenous PEA, restoring its protective, anti-inflammatory and analgesic effects.”
As such, we are simply increasing normal Palmitoylethanolamide actions. Note, some studies referenced are that of Levagen+, of which has the exact mechanism of action, just requires lower doses to reach the same palmitoylethanolamide blood concentrations.
Pain Management
One of the absolute best applications for Levagen is certainly pain management and the most consistent feedback we get at Strom. While it won't be as significant analgesic as many prescription medications, for many people dealing with chronic pain from injuries or other issues, it can be just enough to manage without the medications, providing an alternative that doesn't come with such a strong host of side effects. Here we must remind that a supplement cannot be used to treat or diagnose disease or medical ailments. However for non-medical applications of just helping live life, Levagen can be a great option. BJJ is a common example, where it's common to accumulate a number of minor injuries that may be inhibiting performance. Remember: It is a normal physiological response to inflammation for the body to produce more Palmitoylethanolamide, so by supplementing with it we are simply elevating the normal levels for greater magnitude of effect.
Likely most relevant mechanism of action is the activation and hence desensitisation of TRPV1 channels. Numerous human clinical trials have shown value for pain management.
Anti-inflammatory for Joint Health
A number of clinical trials have investigated anti-inflammatory effects for Levagen and Palmitoylethanolamide, the general consensus is that the mechanisms by which it exerts its anti-inflammatory actions is via downregulation of mast cell activation and increase the synthesis of endocannabinoid 2-Arachidonoylglycerol to reduce histamine response. It is a normal physiological response to inflammation for the body to produce more Palmitoylethanolamide, so by supplementing with it we are simply elevating the normal levels for greater magnitude of effect.
Anti-inflammatory for Immune Function
The first clinical applications of oral PEA formulations in former 1974 Czechoslovakia, of which were specifically for immune function applications. Much like the
W
This is similar to the ethos of Alzchem's CreaPure, it's just creatine... but a creatine we can always have confidence that it is in fact what it claims to be which we can't say for the wider market right now. Levagen is the same.
The role of quality assured products like this are valuable in the supplement industry as we can use the as a benchmark to compare others against. In this case the wider Palmitoylethanolamide industry appears to suffer quality issues, being poor in performance compared to Levagen, some other branded "Pure" PEA products having as low as 50% yield. See reference [x] for third party research regarding
What does naturally occurring Palmitoylethanolamide do in the body?
Palmitoylethanolamide is a naturally occurring compound that our body does already produce, synthesized from palmitic acid, which is the most common fatty acid in animals and a product of normal fatty acid synthesis.
It is generally accepted that most tissues in the body will produce Palmitoylethanolamide in increased concentrations in response to inflammatory stress, whereupon it is freely available to act in an anti-inflammatory manner - including the direct activation of PPAR-a and GPR55 receptors and the indirect activation of cannabinoid receptors (CB1 and CB2) and TRPV1 channels. This has a valuable role in regulation of inflammatory cytokine response, notable for any source of inflammation but with well documented research around joint inflammation, inflammation related immune disorders, brain inflammation, and influenza related. Other research shows functions in sleep modulation.
PEA is endogenously produced on-demand in most tissues, as a protective response to injury, inflammation and pain.
What does Supplemental Palmitoylethanolamide do in the body?
When orally consumed Palmitoylethanolamide is able to enter circulation through the digestive tract. Once in circulation, Palmitoylethanolamide acts on out body in the same way as normally produced Palmitoylethanolamide. When pain is protracted, however, PEA ‘exhaustion’ may develop. Chronic inflammatory conditions create lower levels of PEA. The exogenous administration of PEA may in such cases serve to replenish levels of endogenous PEA, restoring its protective, anti-inflammatory and analgesic effects.”
As such, we are simply increasing normal Palmitoylethanolamide actions. Note, some studies referenced are that of Levagen+, of which has the exact mechanism of action, just requires lower doses to reach the same palmitoylethanolamide blood concentrations.
Pain Management
One of the absolute best applications for Levagen is certainly pain management and the most consistent feedback we get at Strom. While it won't be as significant analgesic as many prescription medications, for many people dealing with chronic pain from injuries or other issues, it can be just enough to manage without the medications, providing an alternative that doesn't come with such a strong host of side effects. Here we must remind that a supplement cannot be used to treat or diagnose disease or medical ailments. However for non-medical applications of just helping live life, Levagen can be a great option. BJJ is a common example, where it's common to accumulate a number of minor injuries that may be inhibiting performance. Remember: It is a normal physiological response to inflammation for the body to produce more Palmitoylethanolamide, so by supplementing with it we are simply elevating the normal levels for greater magnitude of effect.
Likely most relevant mechanism of action is the activation and hence desensitisation of TRPV1 channels. Numerous human clinical trials have shown value for pain management.
- 350mg Levagen+ has been trailed in a 2-week joint pain study, during which Levagen+ provided a statistically significant reduction in perceived pain scores compared to placebo.
- 700mg Levagen+ has been trailed for a 80 person placebo controlled migraine pain study, which provided a statistically statistically significant reduction in perceived pain scores compared to placebo.
- 1200mg umPEA has been trailed in a paediatric population suffering from migraines, which provided a significant reduction in perceived pain, frequency of migraines, and other medication used to assist. This was an open label pilot study and no placebo was used.
Anti-inflammatory for Joint Health
A number of clinical trials have investigated anti-inflammatory effects for Levagen and Palmitoylethanolamide, the general consensus is that the mechanisms by which it exerts its anti-inflammatory actions is via downregulation of mast cell activation and increase the synthesis of endocannabinoid 2-Arachidonoylglycerol to reduce histamine response. It is a normal physiological response to inflammation for the body to produce more Palmitoylethanolamide, so by supplementing with it we are simply elevating the normal levels for greater magnitude of effect.
Anti-inflammatory for Immune Function
The first clinical applications of oral PEA formulations in former 1974 Czechoslovakia, of which were specifically for immune function applications. Much like the
- The use of PEA as a respiratory infection prophylactic among 1386 volunteers and reported a significant reduction in pain, amount of fever episodes, and incidence of respiratory tract infections.
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HOW IS Levagen different to most Palmitoylethanolamide products?
"Levagen® is high quality Palmitoylethanolamide (PEA)."
Key Qualities:
- 99% palmitoylethanolamide, purity guaranteed.
- Vegetarian, Organic, Non-GMO, Kosher, GRAS Affirmed, Halal,
HOW SHOULD I DOSE Levagen?
As with any tool, it's always important to ensure correct dosing with your supplement protocol.
Generally we reccomend a starting dose of 300mg Levagen, and then if the need for greater impact is needed then dosing up to 600mg is supported by research as safe and effective.
Generally we reccomend a starting dose of 300mg Levagen, and then if the need for greater impact is needed then dosing up to 600mg is supported by research as safe and effective.
F.A.Q.
What's the difference between Levagen and Levagen+?"
Levagen®+ is a cold water dispersible palmitoylethanolamide (PEA) powder, designed to increase bioavailability using LipiSperse® technology developed by Pharmako Biotechnologies, Australia.
In aqueous environments (such as the stomach), the Levagen+ particles will more freely disperse than that of Levagen alone, this net effect translates to increased bioavailability.
HOWEVER, as always this comes at a cost. Levagen+ is reduced to 90% palmitoylethanolamide by weight, while Levagen is 100%. Levagen+ also comes at a higher cost than Levagen alone, and so when considering effectiveness per unit of cost, Richard determined Levagen to be a better choice for the Strom range.
Simply put, Levagen+ is theoretically more potent, however the same results will be achieved with either and Levagen+ has a higher cost per effective serve.
Levagen®+ is a cold water dispersible palmitoylethanolamide (PEA) powder, designed to increase bioavailability using LipiSperse® technology developed by Pharmako Biotechnologies, Australia.
In aqueous environments (such as the stomach), the Levagen+ particles will more freely disperse than that of Levagen alone, this net effect translates to increased bioavailability.
HOWEVER, as always this comes at a cost. Levagen+ is reduced to 90% palmitoylethanolamide by weight, while Levagen is 100%. Levagen+ also comes at a higher cost than Levagen alone, and so when considering effectiveness per unit of cost, Richard determined Levagen to be a better choice for the Strom range.
Simply put, Levagen+ is theoretically more potent, however the same results will be achieved with either and Levagen+ has a higher cost per effective serve.